NeuroscienceThe Journal of Headache and PainPeer-reviewed
PN6047 Demonstrates Broad Preclinical Efficacy in Headache Models as a Novel Delta-Opioid Receptor Agonist
Yaseen Awad-Igbaria, Yanping Zhang, Mattin Aframian…·Amynah A. A. Pradhan
This paper evaluates the efficacy of PN6047, a novel DOR agonist, in preclinical headache models and finds it effectively reduces pain and prevents medication overuse headache.
DOI 10.1186/s10194-026-02473-1