Molecular BiologyJournal of NeurochemistryPeer-reviewed
Ischemia-Induced Post-Translational Modifications of GLT-1 Mediate Aberrant Trafficking and Impaired Glutamate Uptake
Simran K. Gill, Katelyn Louise Reeb, Max Kroll…·Andréia C. K. Fontana
This study shows that ischemia-induced ubiquitination of GLT-1 leads to its internalization and reduced glutamate uptake, contributing to neuronal damage, and that disrupting this process can restore function and provide neuroprotection.
DOI 10.1111/jnc.70497