Maxim Balasov

The paper investigates differences in Orc6 protein interactions with the ORC complex in Drosophila and humans, proposing that a nuclear localization signal in humans compensates for weaker binding.

The paper investigates ORC6 mutations in Meier-Gorlin syndrome using a humanized Drosophila model, showing that truncated ORC6 proteins fail to rescue orc6 deletion and that a strong Kozak sequence enables translation from a non-canonical ACG start codon.

This study identifies a direct role of Drosophila STING in lipid metabolism, showing it interacts with lipid synthesis enzymes and affects lipid storage and stress sensitivity.

The paper uses a humanized Drosophila model to study Orc6 mutations in Meier-Gorlin syndrome, showing that N-terminal mutations disrupt DNA binding while C-terminal mutations affect ORC interaction.