Developmental BiologybioRxivPreprint
A structure-selective endonuclease drives uniparental mitochondrial DNA inheritance
Mayu Shimomura, Hwa Young Yun, Philip C. Zuzarte…·Thomas R. Hurd
The paper identifies Hotaru, a testis-specific endonuclease, as essential for paternal mtDNA elimination in sperm, revealing its structural recognition of mtDNA cruciform DNA.
DOI 10.64898/2026.03.19.713005