Author

Melica Nourmoussavi Brodeur

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Melica Nourmoussavi BrodeuriD1 paper · Memorial Sloan Kettering Cancer Center

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Ana Leda F. LonghiniiD· 1 shared Andrea M. GazzoiD· 1 shared Benjamin D. GreenbaumiD· 1 shared Britta WeigeltiD· 1 shared Dmitriy ZamariniD· 1 shared Elisa de StanchinaiD· 1 shared Higinio DopesoiD· 1 shared Hunter GreeniD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Ana Leda F. LonghiniORCID

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1 paper

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedDec 4, 2024

Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity

Melica Nourmoussavi Brodeur, Higinio Dopeso, Yingjie Zhu…·Dmitriy Zamarin

This study shows that SMARCA4 mutations in ovarian cancer increase immunogenicity through interferon response and epigenetic changes, enhancing T cell and NK cell activity in the tumor microenvironment.

26 citations

mousebulk RNA-seq

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