NeuroscienceJournal of NeurosciencePeer-reviewed
A novel mouse model for developmental and epileptic encephalopathy by Purkinje cell-specific deletion of Scn1b
Fernando Isaac Guillén, Mendee A. Geist, Shao-Ying Cheng…·MacKenzie Allen Howard
This study develops a novel mouse model with Purkinje cell-specific Scn1b deletion, revealing cerebellar dysfunction and associated neurological impairments without early mortality.
DOI 10.1523/jneurosci.2184-24.2025