Developmental BiologyEMBO ReportsPeer-reviewed
PRAMEL7/CUL2 axis regulates NuRD stability to establish ground-state pluripotency in embryonic stem cells
Meneka Rupasinghe, Cristiana Bersaglieri, Deena M Leslie Pedrioli…·Raffaella Santoro
This study shows PRAMEL7 interacts with CUL2 to destabilize NuRD complex, promoting ground-state pluripotency in ESCs by reducing repressive chromatin regulation.
DOI 10.1038/s44319-024-00083-z