Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade
A. Magen, P. Hamon, N. Fiaschi, L. Troncoso, E. Humblin, D. D'souza, T. Dawson, M. D. Park, J. Kim, S. Hamel, M. Buckup, C. Chang, A. Tabachnikova, H. Schwartz, N. Malissen, , Merad
The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.
bioRxiv · Jun 22, 2022 · PreprintImmunology