NeurosciencebioRxivPreprint
Cannabidiol targets a modulatory system for excitatory-inhibitory synaptic coordination, contributing to its anti-seizure action
Evan C. Rosenberg, Simon Chamberland, Michaël Bazelot…·Richard W. Tsien
This study investigates how CBD modulates LPI-GPR55 signaling at excitatory and inhibitory synapses, showing its role in reducing seizure activity by blocking LPI's pro-excitatory effects and enhancing inhibitory synaptic strength.
DOI 10.1101/2022.09.27.509638