Author
University of Minnesota
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Elise A. Lamont, Shannon Lynn Kordus, Michael D. Howe…·Anthony D. Baughn
This study shows that MHC II and CD4 T cell help are essential for pyrazinamide's antitubercular efficacy, revealing a host-mediated mechanism for its in vivo activity.
Lev Ostrer, Taylor A. Crooks, Michael D. Howe…·Anthony D. Baughn
This study identifies a dual mechanism of action for morphazinamide, a more potent pyrazinamide analog, showing it kills Mycobacterium tuberculosis through coenzyme A disruption and aldehyde release, which also bypasses resistance.
Akanksha Varshney, Ziyi Jia, Michael D. Howe…·Anthony D. Baughn
The paper shows that MBX-4132, a trans-translation inhibitor, kills Mycobacterium tuberculosis and non-tuberculous mycobacteria, with zinc enhancing its activity and iron reducing it.
Kristin Vill, Lasse van Geelen, Oliver Michel…·Rainer Kalscheuer
This study identifies novel anti-TB pro-drugs based on α-aminooxyacetic acid that are effective against M. tuberculosis and show low cytotoxicity.