Cancer BiologyCell Reports MedicinePeer-reviewed
CD4+ T cell-derived IL21 regulates stem cell fate in acute myeloid leukemia by activation of p38-MAPK signaling
Viviana Rubino, Michelle Hüppi, Sabine Höpner…·Carsten Riether
This study identifies IL21 from CD4+ T cells as a negative regulator of leukemia stem cell self-renewal through ROS and p38-MAPK signaling, with prognostic implications in AML.