Guangshuo Ou

The paper investigates IFT-A-IFT-B coordination in cilia using multiple techniques and finds that BBSome-IFT proximities are essential for their coupling.

This study identifies Janusein as a microtubule-associated protein that cooperates with EB proteins to enhance microtubule plus-end catastrophe.

This study identifies RAT-1 as a regulator of ciliary microtubule dynamics through spatially confined phase separation that stabilizes tubulin availability for MT growth.

The paper develops a framework to rerank protein-protein interactions using structural and biological evidence, improving prediction accuracy over structural-only methods.

This paper develops a hierarchical sequence-based framework to infer distributed protein organization, identifies novel ciliary proteins, and enables synthetic protein design.

This study shows that CPR-4, a homologue of human cathepsin B, induces DNA damage and mutagenesis in C. elegans under crowding stress, leading to increased mutation rates and competitive growth advantages.

TaoChongBao is a database of C. elegans missense variants linked to human pathogenic sites, offering expanded mutation coverage and tools for variant interpretation and comparative genomics.

This study identifies GPCR-Gαq signaling as a mechanism of adaptive resistance to MEK inhibition in BRAF-mutant melanoma, showing that targeting this pathway can restore drug sensitivity.

The paper shows fasting improves locomotion in C. elegans lacking UNC-31/CAPS by activating octopamine-Gαq signaling through upregulation of egl-30.

The paper systematically assesses the functional impact of all TUBA1A missense variants using experimental and computational methods, improving clinical variant classification.

This study identifies FAP53 as a key factor in B-tubule assembly during microtubule doublet formation and shows its role in ciliogenesis across species.

SynSeg generates synthetic datasets to train a U-net model for subcellular segmentation, outperforming traditional methods in vesicle and cytoskeletal filament detection.

This study shows that phosphorylation of the elbow region in kinesin OSM-3 regulates its autoinhibition, with phosphorylation mutants affecting cilia entry and motility.

The paper develops an AI-driven method to label tubulin isotypes in vivo across species, enabling precise visualization of microtubule dynamics and pathogenic variants without disrupting cellular processes.

The paper introduces a cost-effective WGS method for model organisms to validate missense variant predictions.

The paper develops a machine learning-based EMS mutagenesis probability map to identify causal mutations in C. elegans without generating recombinant inbred lines.

ADAMS aligns distance matrices using SIFT to improve protein structure comparison, matching Foldseek's performance while better handling flexible structures.

The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.

The paper shows that V-ATPase asymmetrically segregates the NuRD complex during cell division, influencing daughter cell survival or apoptosis through pH differences.

This study investigates the role of spectrin-based membrane mechanics in neuronal migration and dendrite formation in C. elegans, showing that spectrin's asymmetry and remodeling are critical for proper development.