Cell BiologybioRxivPreprint
Deacetylation of catalytic lysine in CDK1 is essential for Cyclin-B binding and cell cycle
Shaunak Deota, Sivasudhan Rathnachalam, Kanojia Namrata…·Ullas Kolthur-Seetharam
This study shows that acetylation of catalytic lysine in CDK1 regulates Cyclin-B binding, with SIRT1 and P300 opposing this modification, and that acetylation mimics in yeast block cell cycle progression.
DOI 10.1101/420000