Author

Krishna Kant Vishwakarma

Tata Institute of Fundamental Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ullas Kolthur‐SeetharamiD· 2 shared Amit FulzeleiD· 1 shared Anne Gonzalez de PeredoiD· 1 shared Chinthapalli Balaji· 1 shared Kanojia Namrata· 1 shared Mayank Boob· 1 shared Mithilesh Mishra· 1 shared Rashna BhandariiD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

Ullas Kolthur‐SeetharamORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiophysicsProteins Structure Function and BioinformaticsPeer-reviewedJul 16, 2024

ATP-Binding Free Energy Simulations Reveal an Allosteric Link Between the Enzyme Active Site and Multiple Functional Protein-Protein Interaction Interfaces in Cyclin Dependent Kinase-1

Krishna Kant Vishwakarma, Ullas Kolthur‐Seetharam, Ravindra Venkatramani

The paper uses molecular dynamics simulations to show that ATP binding free energy in CDK1 is affected by acetylation at the active site and reveals non-local entropy changes linked to protein-protein interactions.

2 citations

humanstructural biology

𝕏 PostBluesky

Cell BiologybioRxivPreprintSep 20, 2018

Deacetylation of catalytic lysine in CDK1 is essential for Cyclin-B binding and cell cycle

Shaunak Deota, Sivasudhan Rathnachalam, Kanojia Namrata…·Ullas Kolthur-Seetharam

This study shows that acetylation of catalytic lysine in CDK1 regulates Cyclin-B binding, with SIRT1 and P300 opposing this modification, and that acetylation mimics in yeast block cell cycle progression.

DOI 10.1101/420000

yeastexperimental assay

𝕏 PostBluesky