Author

Muhammad S. Khan

University of North Carolina at Chapel Hill

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Biology Disciplines

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Biophysics· 1

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Approach:experimental assay· 1 Assay:structural biology· 1

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Andrew L. LeeiD· 1 shared Jeffrey AubéiD· 1 shared Kelin LiiD· 1 shared Paul J. SapienzaiD· 1 shared Trevor R. MileuriD· 1 shared

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1 shared paperBiophysics

Andrew L. LeeORCID

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1 paper

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BiophysicsbioRxivPreprintAug 21, 2026

Dynamic view of an allosteric intermediate in a positively cooperative dimer

Paul J. Sapienza, Trevor R. Mileur, Muhammad S. Khan…·Andrew L. Lee

This paper stabilizes and analyzes the singly-bound intermediate of chorismate mutase to reveal that positive cooperativity arises from dynamic ensemble behavior rather than a simple two-state switch.

DOI 10.64898/2026.08.11.744235

structural biologyexperimental assay

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