Jeffrey Aubé

This paper stabilizes and analyzes the singly-bound intermediate of chorismate mutase to reveal that positive cooperativity arises from dynamic ensemble behavior rather than a simple two-state switch.

This paper shows that disrupting riboflavin biosynthesis in Mycobacterium tuberculosis leads to metabolic changes and loss of infectivity in mice.

This paper shows that inhibiting HuR reduces hypertension and fibrosis in chronic kidney disease by targeting inflammation, oxidative stress, and vascular dysfunction.

This study identifies diverse TCR repertoires in CD4+ MAIT cells, showing they use non-TRAV1-2 TCRs and may recognize alternative MR1 ligands.

This study identifies a non-catalytic function of SETD2 in maintaining nuclear lamina stability and genome integrity through its N-terminus interactions.

This study shows that MAIT cells respond to extracellular and intracellular pathogens via distinct antigen-presenting cells, with type-17 MAIT cells responding to Acinetobacter baumannii and type-1 MAIT cells to Francisella tularensis.

This study shows MAIT cells inhibit colon cancer growth in mice by modulating immune responses and increasing eosinophil-related cytokines.

This study shows that inhibiting HuR reduces cardiac remodeling after ischemia-reperfusion injury by dampening inflammatory gene expression and immune response, but not initial infarct size.

This study shows that HuR-dependent Wisp1 expression is necessary for TGFβ-induced cardiac myofibroblast activity, as HuR inhibition reduces ECM remodeling and contractile functions.

The paper compiles an annotated set of 171 small molecule modulators targeting 98 novel AD therapeutic proteins, serving as chemical tools for hypothesis validation.