ImmunologybioRxiv
T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFa Inflammation.
N. W. Cho, S. M. Guldberg, B. Y. Nabet…·M. H. Spitzer
The paper identifies a novel mechanism of ICI resistance where T cells drive inflammatory resistance via IL-1 and TNF in tumors, with implications for therapy.