Inherent evolutionary unpredictability in cancer model system
S. Chattopadhyay, J. Karlsson, A. Manas, R. Kanzaki, E. Fredlund, A. J. Murphy, C. L. Morton, M. A. Woolard, N. Andersson, K. Hansson, K. Radke, A. M. Davidoff, S. Mohlin, K. Pietras, D. Bexell, D. Gisselsson
This study shows that cancer evolution can be inherently unpredictable, using agent-based models and patient-derived xenograft data to demonstrate chaotic clonal dynamics.
bioRxiv · Jun 1, 2022Evolutionary Biology