A. Manas

PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance

The paper identifies PRDX6 as an alternative pathway for selenocysteine metabolism that contributes to ferroptosis resistance in cancer cells.

Inherent evolutionary unpredictability in cancer model system

This study shows that cancer evolution can be inherently unpredictable, using agent-based models and patient-derived xenograft data to demonstrate chaotic clonal dynamics.

Clinically-relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance

The paper applies a clinically-relevant chemotherapy regimen to neuroblastoma PDX models to identify transcriptional patterns and mechanisms of chemoresistance.

Engineering of human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia and solid tumor metastasis

This study develops standardized humanized mini-bones to model hematopoiesis, leukemia, and solid tumor metastasis by engrafting human blood and cancer samples.

Detection of melanin-mediated false-positive for BaxΔ2 immunohistochemical staining in human skin tissue

The paper identifies that melanin in skin tissue causes false-positive BaxΔ2 immunostaining in the epidermis, but not in dermal connective tissues.

Detection of Pro-apoptotic BaxΔ2 Proteins in the Human Cerebellum

The paper reports the presence of BaxΔ2 protein in human cerebellar tissues, with varying expression levels across Purkinje cells and associated genetic mutations.