Central and peripheral tau retention modulated by an anti-tau antibody.
A. Solorzano, M. Brady, N. Bhatt, A. Peterson, B. Burgess, H. Leyva, N. Puangmalai, C. Jerez, R. Wood, R. Kayed, R. Deane
This study investigates the body-wide distribution and retention of CSF-derived tau protein, showing increased uptake in aging and APP/PS1 mice, and demonstrates the effect of anti-tau antibodies on its clearance and accumulation in different organs.
bioRxiv · Aug 17, 2023 · PreprintPhysiology