R. Kayed

Identification of retinal tau oligomers, citrullinated tau, and other tau isoforms in early and advanced AD and relations to disease status

This study quantifies retinal tau isoforms in early and advanced AD and links them to brain pathology and cognitive status.

Central and peripheral tau retention modulated by an anti-tau antibody.

This study investigates the body-wide distribution and retention of CSF-derived tau protein, showing increased uptake in aging and APP/PS1 mice, and demonstrates the effect of anti-tau antibodies on its clearance and accumulation in different organs.

Distinct neurotoxic TDP-43 fibril polymorphs can be generated by heterotypic interactions with α-synuclein

This study shows that α-synuclein can generate distinct TDP-43 fibril polymorphs through heterotypic interactions, leading to synaptic dysfunction.

Untwisted α-synuclein Filaments formed in the Presence of Lipid Vesicles

This study investigates the structure of α-synuclein filaments formed in the presence of lipid vesicles, revealing untwisted structures not previously observed in vitro.

The amyloid concentric β-barrel hypothesis: Models of amyloid beta 42 oligomers and annular protofibrils

The paper proposes concentric β-barrel models of Aβ42 oligomers and compares their dimensions to electron micrographs of annular protofibrils.

Distinct cryo-EM Structure of α-synuclein Filaments derived by Tau

This study reports a cryo-EM structure of α-synuclein filaments promoted by tau, revealing distinct conformations compared to in vitro filaments.