Author

N. D. Marino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 3 Assay:DNA methylation· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

J. Bondy-Denomy· 3 shared R. Pinilla-Redondo· 2 shared A. G. Mendoza· 1 shared A. M. Cygan· 1 shared A. Talaie· 1 shared C. M. Brown· 1 shared H. Carion· 1 shared J. C. Boothroyd· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersMicrobiology

J. Bondy-Denomy

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4 papers

Recent·Most cited

MicrobiologybioRxivPreprintNov 29, 2022

Translation-dependent downregulation of Cas12a mRNA by an anti-CRISPR protein

N. D. Marino, A. Talaie, H. Carion…·J. Bondy-Denomy

This study shows that AcrVA2 inhibits Cas12a mRNA translation, reducing its anti-phage activity and enabling specific inhibition of Cas12a orthologs.

DOI 10.1101/2022.11.29.518452

bacteria (other)experimental assay

𝕏 PostBluesky

MicrobiologybioRxivMar 10, 2022

CRISPR-Cas12a targeting of ssDNA plays no detectable role in immunity

N. D. Marino, R. Pinilla-Redondo, J. Bondy-Denomy

This study shows that CRISPR-Cas12a's ssDNA cleavage activities do not contribute to bacterial immunity, as they do not affect cell viability or provide protection against ssDNA invaders.

DOI 10.1093/nar/gkac462

bacteria (other)DNA methylation

𝕏 PostBluesky

MicrobiologybioRxivMay 22, 2020

Discovery of multiple anti-CRISPRs uncovers anti-defense gene clustering in mobile genetic elements

R. Pinilla-Redondo, S. Shehreen, N. D. Marino…·J. Bondy-Denomy

The paper identifies 11 new anti-CRISPR genes in Enterobacteriaceae and Pseudomonas, revealing their clustering with other anti-defense genes in genomic regions called 'anti-defense islands'.

DOI 10.1038/s41467-020-19415-3

bacteria (other)DNA methylation

𝕏 PostBluesky

MicrobiologybioRxivDec 6, 2019

Co-immunoprecipitation with MYR1 identifies three additional proteins within the Toxoplasma parasitophorous vacuole required for translocation of dense granule effectors into host cells

A. M. Cygan, T. C. Theisen, A. G. Mendoza…·J. C. Boothroyd

The paper identifies three new proteins interacting with MYR1 in Toxoplasma that are essential for translocating effector proteins into host cells.

DOI 10.1128/msphere.00858-19

experimental assayhost-pathogen & immune response

𝕏 PostBluesky