Chemogenetic analysis of how receptors for short chain fatty acids regulate the gut-brain axis
A. B. Tobin, N. Barki, D. Bolognini, U. Borjesson, L. Jenkins, J. Riddell, D. I. Hughes, T. Ulven, B. D. Hudson, E. R. Ulven, N. Dekker, G. Milligan
This study identifies a specific agonist for a modified FFA2 receptor and demonstrates distinct roles of FFA2 and FFA3 in gut-brain communication using genetically engineered mice.
bioRxiv · Jan 11, 2020Pharmacology & Toxicology