An engineered monomer binding-protein for α-synucleinefficiently inhibits the proliferation of amyloid fibrils
E. D. Agerschou, T. Saridaki, P. Flagmeier, C. Galvagnion, D. Komnig, A. Nagpal, N. Gasterich, L. Heid, V. Prasad, H. Shaykhalishahi, A. Voigt, D. Willbold, C. M. Dobson, B. H. Falkenburger, W. Hoyer, A. K. Buell
The paper engineers a monomer-binding protein that inhibits α-synuclein fibril proliferation in vitro and in vivo, showing it reduces aggregates and related pathologies.
bioRxiv · Mar 5, 2019Bioengineering