Author

N. Hajicek

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Biochemistry· 1

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1

Frequent Co-Authors

B. R. S. Temple· 1 shared E. Siraliev-Perez· 1 shared J. E. Burke· 1 shared J. Sondek· 1 shared J. T. Stariha· 1 shared M. L. Jenkins· 1 shared Q. Zhang· 1 shared R. M. Hoffmann· 1 shared

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2022-2022 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperBiochemistry

B. R. S. Temple

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1 paper

Recent·Most cited

BiochemistrybioRxivFeb 23, 2022

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

E. Siraliev-Perez, J. Sondek, B. R. S. Temple…·M. L. Jenkins

This study shows that PLC-gamma1 becomes active upon binding to FGFR1 kinase domain and membrane-bound PIP2, with an oncogenic mutation enhancing this activation.

DOI 10.7554/elife.77809

experimental assaycell signaling & trafficking

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