BiochemistrybioRxiv
Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications
N. J. Henning, A. G. Manford, J. N. Spradlin…·D. K. Nomura
The paper discovers a covalent ligand, EN106, that targets FEM1B for PROTAC-based protein degradation, demonstrating its utility in degrading BRD4.
DOI 10.1021/jacs.1c03980