Author

N. J. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

J. L. J. Coleman· 2 shared R. M. Graham· 2 shared T. Ngo· 2 shared A. G. Reidenbach· 1 shared A. Husain· 1 shared A. J. Cleave· 1 shared A. M. E. Faust· 1 shared A. M. Finch· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPharmacology & Toxicology

J. L. J. Coleman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Diversity-oriented synthesis encoded by deoxyoligonucleotides

L. Hudson, J. W. Mason, M. V. Westphal, M. J. R. Richter, J. R. Thielman, B. K. Hua, C. J. Gerry, G. Xia, H. L. Osswald, J. M. Knapp, Z. Y. Tan, P. Kokkonda, B. I. C. Tresco, S. Liu, A. G. Reidenbach, , K. Briner

The paper describes the design, synthesis, and validation of a 3.7 million-member DNA-encoded library using diversity-oriented synthesis to enhance structural diversity for drug discovery.

bioRxiv · Oct 16, 2022Biochemistry

Standardised method for cardiomyocyte isolation and purification from individual murine neonatal, infant, and adult hearts

A. M. Nicks, S. R. Holman, A. Y. Chan, M. Tsang, P. E. Young, D. T. Humphreys, N. Naqvi, A. Husain, M. Li, N. J. Smith, S. E. Iismaa, R. M. Graham

This paper develops a standardized method to isolate and purify high-quality cardiomyocytes from murine hearts of all postnatal ages, revealing sex-specific genes and preserving cell morphology.

bioRxiv · Sep 30, 2021Cell Biology

Orphan G protein-coupled receptor, GPR37L1: pharmacological toolbox empty once again

T. Ngo, B. P. Wilkins, S. S. So, P. Keov, K. K. Chahal, A. M. Finch, J. L. J. Coleman, I. Kufareva, N. J. Smith

The paper corrects a cloning error in a 2017 study on GPR37L1 ligand discovery and reports unsuccessful re-testing of predicted ligands, leading to a retraction initiative.

bioRxiv · Sep 11, 2020 · PreprintPharmacology & Toxicology

The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases

J. L. J. Coleman, T. Ngo, R. E. Smythe, A. J. Cleave, N. M. Jones, R. M. Graham, N. J. Smith

This study identifies matrix metalloprotease-mediated cleavage of GPR37L1's N-terminus as a regulatory mechanism that inactivates the receptor.

bioRxiv · Jun 27, 2020Biochemistry