Author

G. Xia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 2 Assay:metagenomics· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

B. Melillo· 2 shared A. G. Reidenbach· 1 shared A. M. E. Faust· 1 shared A. McGrath· 1 shared A. Xu· 1 shared B. Gu· 1 shared B. I. C. Tresco· 1 shared B. K. Hua· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

B. Melillo

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural Basis for the Activation of Proteinase-Activated Receptors (PARs) by Endogenous Ligands

Z. Lyu, X. Lyu, G. Xia, D. Carney, V. M. Alves, M. Falk, N. Arora, H. Zou, A. McGrath, Y. Kang

This study presents structural insights into PAR1 and PAR2 activation by endogenous ligands, revealing a novel mechanism and potential targets for therapeutic development.

bioRxiv · Jul 8, 2024 · PreprintBiochemistry

WTAP, transcriptionally regulated by p65, promotes inflammation through m6A modification and phase separation

Y. Ge, R. Chen, T. Ling, B. Liu, J. Huang, Y. Cheng, Y. Lin, H. Chen, X. Xie, G. Xia, G. Luo, S. Yuan, A. Xu

This study identifies WTAP as a p65-regulated m6A writer that promotes inflammation via phase separation and m6A modification, offering a therapeutic target for hyperinflammation.

bioRxiv · Oct 30, 2023 · PreprintImmunology

Genetic crosses within and between species of Cryptosporidium

S. Shaw, I. S. Cohn, R. de Paula Baptista, G. Xia, B. Melillo, F. Agyabeng-Dadzie, J. C. Kissinger, B. Striepen

This paper demonstrates genetic crosses within and between Cryptosporidium species, showing genomic recombination and its implications for parasite adaptation and host specificity.

bioRxiv · Aug 4, 2023Microbiology

Diversity-oriented synthesis encoded by deoxyoligonucleotides

L. Hudson, J. W. Mason, M. V. Westphal, M. J. R. Richter, J. R. Thielman, B. K. Hua, C. J. Gerry, G. Xia, H. L. Osswald, J. M. Knapp, Z. Y. Tan, P. Kokkonda, B. I. C. Tresco, S. Liu, A. G. Reidenbach, , K. Briner

The paper describes the design, synthesis, and validation of a 3.7 million-member DNA-encoded library using diversity-oriented synthesis to enhance structural diversity for drug discovery.

bioRxiv · Oct 16, 2022Biochemistry

Effects of Cr stress on bacterial community structure and diversity in rhizosphere soils of Iris pseudacorus

Z. sixi, W. Zhao, X. Yang, G. Xia, B. Wang, B. Gu

This study examines how chromium stress affects bacterial community structure and diversity in the rhizosphere soils of Iris pseudacorus using 16S rRNA sequencing.

bioRxiv · Aug 11, 2022 · PreprintMicrobiology

Comprehensive proteomic and metabolomic profiling of mcr-1 mediated colistin resistance in Escherichia coli

H. Li, Y. Wang, Q. Meng, Y. Wang, G. Xia, X. Xia, J. Shen

This study identifies proteomic and metabolomic changes in Escherichia coli mediated by mcr-1, showing altered lipid metabolism and efflux pump activity contribute to colistin resistance.

bioRxiv · Oct 3, 2018Pharmacology & Toxicology