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Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants

A nanoparticle vaccine candidate induces broadly neutralizing antibodies against multiple SARS-CoV-2 variants through enhanced immune responses.

Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

This study isolates HIV-1 neutralizing antibodies from mice and rabbits immunized with gp41-stabilized trimers and nanoparticles, showing they target different epitopes and elicit Env-dependent breadth.

Evolution of Modularity, Interactome and Functions of GIV/Girdin (CCDC88A) from Invertebrates to Vertebrates

The paper examines the evolutionary changes in GIV/Girdin's modularity, interactome, and functions across invertebrates and vertebrates, revealing distinct roles in cancer as tumor suppressor or oncogene.

Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates

The paper develops SARS-CoV-2 vaccine candidates by displaying the receptor-binding domain and a stabilized spike on self-assembling protein nanoparticles, showing enhanced neutralizing antibody and T-cell responses.

Orphan G protein-coupled receptor, GPR37L1: pharmacological toolbox empty once again

The paper corrects a cloning error in a 2017 study on GPR37L1 ligand discovery and reports unsuccessful re-testing of predicted ligands, leading to a retraction initiative.

Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

The paper identifies CNS-specific immune alterations in COVID-19 patients with neurological symptoms, suggesting neuroinvasion and anti-neural autoimmunity as potential causes.

Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines

This study designs and tests Ebola virus vaccines using stabilized GP trimers displayed on nanoparticles, showing they induce neutralizing antibodies and enhance infection.

Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi

This study identifies how receptor tyrosine kinases activate heterotrimeric G proteins through phosphorylation of Gi's interdomain cleft tyrosines, revealing a tyrosine-based signaling mechanism with implications in cancer.

The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases

This study identifies matrix metalloprotease-mediated cleavage of GPR37L1's N-terminus as a regulatory mechanism that inactivates the receptor.

Functional anatomy of the full length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis

A systematic structure-guided mutagenesis study of chemokine receptor CXCR4 reveals novel insights into epitopes regulating ligand recognition, ligand specificity and CXCL12-mediated signaling.

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

This paper determines the structure of the CXCR4-CXCL12 complex using crosslinking, revealing the geometry and selectivity determinants of CXC receptor-chemokine interactions.