Author

N. Jasani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 4 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

F. A. Karreth· 4 shared X. Xu· 4 shared I. Bok· 3 shared O. Vera· 3 shared K. Nakamura· 2 shared K. Wang· 2 shared K. Y. Tsai· 2 shared A. Angarita· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCancer Biology

F. A. Karreth

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4 papers

Recent·Most cited

MAPK-mediated PHGDH induction is essential for melanoma formation and represents an actionable vulnerability

N. Jasani, X. Xu, B. Posorske, Y. Kim, O. Vera, K. Y. Tsai, G. M. DeNicola, F. A. Karreth

This study identifies PHGDH induction via MAPK and mTORC1 pathways as essential for melanoma formation and shows that combining BRAFV600E inhibition with serine restriction can target this vulnerability.

bioRxiv · Apr 11, 2024 · PreprintCancer Biology

The lipid phosphatase activity of PTEN dampens FRA1 expression via AKT/mTOR signaling to suppress melanoma

X. Xu, I. Bok, N. Jasani, K. Wang, M. Chadourne, O. Deng, E. A. Welsh, F. Kinose, U. Rix, F. A. Karreth

This study shows PTEN's lipid phosphatase activity suppresses melanoma by inhibiting AKT/mTOR signaling and reducing FRA1 expression.

bioRxiv · Jun 1, 2023Cancer Biology

MAPK-induced miR-29 targets MAFG and suppresses melanoma development

O. Vera, I. Bok, N. Jasani, K. Nakamura, X. Xu, N. Mecozzi, A. Angarita, K. Wang, K. Y. Tsai, F. A. Karreth

This study shows that MAPK-induced miR-29 suppresses melanoma by targeting MAFG, and its inactivation accelerates tumor development.

bioRxiv · Jan 27, 2020Cancer Biology

A versatile ES cell-based melanoma mouse modeling platform

I. Bok, O. Vera, X. Xu, N. Jasani, K. Nakamura, J. Reff, A. Nenci, J. G. Gonzalez, F. A. Karreth

This paper develops an ESC-based melanoma mouse model platform to rapidly generate genetically engineered mice for melanoma research using multiple genetic strategies.

bioRxiv · Aug 31, 2019Cancer Biology