Author

N. Krivec

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2

Frequent Co-Authors

C. Spits· 4 shared Y. Lei· 4 shared D. Al Delbany· 3 shared E. Couvreu de Deckersberg· 3 shared K. D. Sermon· 3 shared M. Regin· 3 shared A. E. Huyghebaert· 1 shared A. Keller· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersCell Biology

C. Spits

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

De novo cancer mutations frequently associate with recurrent chromosomal abnormalities during long-term human pluripotent stem cell culture

D. Al Delbany, M. S. Ghosh, N. Krivec, A. E. Huyghebaert, M. Regin, C. M. Duong, Y. Lei, K. D. Sermon, C. Olsen, C. Spits

This study tracks genetic changes in human pluripotent stem cells over time, finding that recurrent chromosomal gains drive the accumulation of other mutations.

bioRxiv · Jul 1, 2024 · PreprintCell Biology

Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity

N. Krivec, E. Couvreu de Deckersberg, Y. Lei, D. Al Delbany, M. Regin, S. Verhulst, L. A. van Grunsven, K. Sermon, C. Spits

This study shows that 1q gain in hESCs increases MDM4 expression, giving a growth advantage during differentiation by reducing DNA damage sensitivity and altering differentiation capacity.

bioRxiv · Sep 19, 2023Cell Biology

SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss

C. Spits, Y. Lei, D. Al Delbany, N. Krivec, M. Regin, E. Couvreu de Deckersberg, C. Janssens, M. Ghosh, K. D. Sermon

This study shows that loss of chromosome 18q in human embryonic stem cells impairs neuroectoderm commitment and cardiac progenitor differentiation through SALL3 downregulation.

bioRxiv · Jun 26, 2023 · PreprintCell Biology

Gains of 12p13.31 delay WNT-mediated initiation of hPSC differentiation and promote residual pluripotency in a cell cycle dependent manner

A. Keller, Y. Lei, N. Krivec, E. Couvreu De Deckersberg, D. Dziedzicka, C. Markouli, K. D. Sermon, M. Geens, C. Spits

This study shows that gains of 12p13.31 in hPSC delay WNT signaling and promote residual pluripotency through NANOG and GDF3, dependent on cell cycle position during differentiation.

bioRxiv · May 22, 2021 · PreprintCell Biology