Cancer BiologybioRxivPreprint
Amplification of genomic regions harbouring genes with dose-limiting effects provides selection pressure for acquiring aberrant epigenetic silencing in ovarian cancer
N. Bonito, I. Eringyte, N. Masrour…·E. Curry
The paper shows that genomic copy number gains in ovarian cancer are associated with promoter methylation, which suppresses gene expression, and demonstrates this through functional experiments.
DOI 10.1101/630228