R. Brown

G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer

This study identifies G-quadruplex structures as regulators of long-range transcriptional reprogramming in drug-resistant ovarian cancer, showing their role in promoting resistance and potential as therapeutic targets.

Novel phylogenomic inference and 'Out of Asia' biogeography of cobras, coral snakes, and their allies

The paper infers the evolutionary relationships and biogeography of cobras and coral snakes, rejecting an 'Out of Africa' hypothesis and supporting an 'Out of Asia' scenario.

The circulating immune cell landscape stratifies metastatic burden in breast cancer patients

This study identifies immune cell signatures in peripheral blood that correlate with metastatic burden in breast cancer patients using single-cell transcriptomics.

cMYC-mediated immune repression is reversed by inhibition of H3K9/H3K27 methylation maintenance

This study shows that inhibiting H3K27/H3K9 methylation maintenance reverses cMYC-mediated immune repression in cancer, improving survival in mouse models.

Volumetrically tracking retinal and choroidal structural changes in central serous chorioretinopathy

This study develops an algorithm to track 3D structural changes in CSCR using OCT scans without prior layer segmentation, enabling automated monitoring of disease progression and treatment response.

Stress-Induced Mucin 13 Reductions Drive Intestinal Microbiome Shifts and Despair Behaviors

This paper identifies mucin 13 as a stress-induced regulator of microbiome shifts and despair behaviors in mice.

P1 bacteriophage-enabled delivery of CRISPR-Cas9 antimicrobial activity against Shigella flexneri

This study uses a P1 bacteriophage to deliver CRISPR-Cas9 for targeted killing of Shigella flexneri in zebrafish larvae, reducing bacterial load and improving survival.

Dual inhibition of SHP2 and autophagy suppresses NF1-associated Malignant Peripheral Nerve Sheath Tumors

This study shows that combining SHP2 and autophagy inhibition effectively suppresses NF1-associated MPNSTs in mouse models, suggesting a potential new treatment approach.

An ACAT inhibitor regulates SARS-CoV-2 replication and antiviral T cell activity

This paper shows that ACAT inhibitors like Avasimibe reduce SARS-CoV-2 replication and enhance antiviral T cell activity in patients.

An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant viral replication in rhesus macaques

An intranasal SARS-CoV-2 beta variant subunit booster vaccine induced protective immunity against beta variant infection in rhesus macaques one year after initial vaccination.

Optimization of Non-Coding Regions Improves Protective Efficacy of an mRNA SARS-CoV-2 Vaccine in Nonhuman Primates

This study compares two mRNA SARS-CoV-2 vaccines in nonhuman primates, showing that CV2CoV, with optimized non-coding regions, provides better immune responses and protection than CVnCoV.

Combined single cell proteomics and transcriptomics reveals discrete human tendon cells populations persist in vitro and on fibrous scaffolds

The paper identifies discrete human tendon cell populations using combined single cell proteomics and transcriptomics, showing some persist in vitro and on fibrous scaffolds, with pro-inflammatory clusters enriched on aligned fibres.

A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates

This paper describes a protein subunit vaccine candidate produced in yeast that protects non-human primates against SARS-CoV-2, showing high neutralizing antibody titers and reduced viral loads after challenge.

Measuring the exposure of primate reservoir hosts to mosquito vectors in Malaysian Borneo

The paper uses thermal imaging and mosquito traps to assess mosquito exposure to long-tailed macaques in Malaysian Borneo, finding higher abundance of Anopheles balabacensis near sleeping sites and detecting Plasmodium inui in both mosquitoes and macaques.

Dual G9A and EZH2 inhibition stimulates an anti-tumour immune response in ovarian high-grade serous carcinoma

This study shows that dual inhibition of G9A and EZH2 in ovarian cancer enhances anti-tumour immune responses by altering the immune microenvironment and reducing tumour growth.

The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

The paper identifies SARS-CoV-2 T-cell epitope variants that reduce recognition by T-cells, highlighting the risk of immune evasion.

Chromatin accessibility changes at intergenic regions associates with ovarian cancer drug resistance

The paper examines chromatin accessibility changes in ovarian cancer cell lines resistant to platinum-based chemotherapy, finding intergenic region alterations linked to drug resistance and Pt-adduct distribution.

Low-Dose Ad26.COV2.S Protection Against SARS-CoV-2 Challenge in Rhesus Macaques

This study shows that low doses of Ad26.COV2.S vaccine protect rhesus macaques against SARS-CoV-2 challenge, with higher doses needed for upper respiratory tract protection.

Deep mining of early antibody response in COVID-19 patients yields potent neutralisers and reveals high level of convergence

The paper identifies potent neutralising antibodies from early COVID-19 patient samples and shows high convergence in antibody sequences across studies.

Effects of ploidy and salmonid alphavirus infection on the skin and gill microbiome of Atlantic salmon (Salmo salar)

This study compares the skin and gill microbiome of diploid and triploid Atlantic salmon, finding ploidy affects gill microbiome diversity and susceptibility to pathogens.

Path tortuosity changes the transport cost paradigm in terrestrial animals

The paper shows that path tortuosity affects transport cost in terrestrial animals, with minimum cost of transport speed decreasing as tortuosity increases.

Why did the animal turn? Time-varying step selection analysis for inference between observed turning points in high frequency data

This paper introduces tiSSA, a time-varying step selection analysis method for high-frequency animal movement data, showing it provides more accurate insights than traditional methods.

REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters

This study evaluates the efficacy of the REGN-COV2 antibody cocktail in preventing and treating SARS-CoV-2 infection in rhesus macaques and hamsters, showing reduced virus load and pathological effects.

Primary platinum resistance and immune exclusion in ovarian carcinomas with high expression of the homologous recombination mediator RAD51

This study shows that high RAD51 expression in ovarian cancer is linked to poor survival and platinum resistance, particularly in HRD-negative tumors, and correlates with immune exclusion.

Single-cell transcriptomic analysis of antiviral responses and viral antagonism in Chikungunya virus-infected synovial fibroblasts

The paper uses single-cell RNA-seq to analyze antiviral responses and viral antagonism in Chikungunya virus-infected synovial fibroblasts, identifying interferon-stimulated genes and immune-related pathways.

Impact of glycan positioning on HIV-1 Env glycan shield density, function, and antibody recognition

This study shows how changes in individual glycan units of HIV-1 Env affect structure, function, and antibody recognition through high-resolution glycomics and molecular dynamics.

Identification of human tendon cell populations in healthy and diseased tissue using combined single cell transcriptomics and proteomics

This study identifies eight distinct human tendon cell populations in healthy and diseased tissue using single-cell CITE-sequencing, revealing disease-specific changes in cell composition and marker expression.

Species delimitation in the grey zone: introgression obfuscates phylogenetic inference and species boundaries in a cryptic frog complex (Ranidae: Pulchrana picturata)

This study shows that introgression in cryptic frog populations can mislead species delimitation methods, leading to overestimated species boundaries in the grey zone of speciation.

Gut microbiota differently contributes to intestinal immune phenotype and systemic autoimmune progression in female and male lupus-prone mice

This study shows that gut microbiota influences intestinal immune responses and autoimmune progression differently in male and female lupus-prone mice, with gender-specific effects on disease susceptibility.

Pretreatment with yeast derived complex dietary-polysaccharide leads to suppressed gut inflammation, altered microbiota composition and increased immune regulatory short-chain fatty acid production in C57BL/6 mice

This study shows that pretreatment with yeast-derived beta-glucans reduces DSS-induced colitis in mice by altering gut microbiota and increasing SCFA production, but loses efficacy when administered during disease onset.