PathologybioRxiv
Lysyl oxidase-dependent subendothelial matrix stiffening promotes RAGE-mediated retinal endothelial activation in diabetes
S. Chandrakumar, I. Santiago Tierno, M. Agarwal…·K. Ghosh
This study shows that LOX-dependent matrix stiffening, regulated by RAGE, promotes retinal endothelial activation in diabetes, suggesting new therapeutic targets for diabetic retinopathy.
DOI 10.2337/db22-0761