M. Agarwal

Stiffness Measurement of Retinal Capillaries and Subendothelial Matrix using Atomic Force Microscopy

The paper provides a protocol for measuring retinal capillary and subendothelial matrix stiffness in mice using atomic force microscopy.

CD8 T-cell dysfunction is linked with CAR T-cell failure and can be mitigated by a non-alpha IL-2 agonist, pegenzileukin

The paper identifies dysfunctional CD8 CAR T-cells in rrLBCL tumors and shows that pegenzileukin mitigates this dysfunction, improving CAR T-cell responses.

Mechanical regulation of retinal vascular inflammation and degeneration in diabetic retinopathy

This study shows that retinal vascular stiffening, caused by LOX overexpression, mechanically regulates inflammation and degeneration in diabetic retinopathy, and that inhibiting LOX prevents these effects.

Lysyl oxidase-dependent subendothelial matrix stiffening promotes RAGE-mediated retinal endothelial activation in diabetes

This study shows that LOX-dependent matrix stiffening, regulated by RAGE, promotes retinal endothelial activation in diabetes, suggesting new therapeutic targets for diabetic retinopathy.

Transcriptional and post-transcriptional regulation of young genes in plants

This study investigates how transcriptional and post-transcriptional mechanisms regulate young genes in plants, finding that they are expressed at low levels and subject to additional decay processes.

Cell Stiffening Contributes to Complement-mediated Injury of Choroidal Endothelial Cells in Early AMD

This study shows that cell stiffness and cytoskeletal regulators Rac and Rho influence complement-mediated injury in choroidal endothelial cells in early AMD.

Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Proteinco-immunization in rhesus macaques

This study compares DNA and DNA+protein vaccines in rhesus macaques, finding that co-immunization with both induces stronger antibody responses and better control of SARS-CoV-2 infection.

SARS-CoV-2 B.1.617.2 Delta variant replication, sensitivity to neutralising antibodies and vaccine breakthrough

This study evaluates the replication, antibody sensitivity, and vaccine efficacy of the SARS-CoV-2 B.1.617.2 Delta variant compared to other variants and vaccine-elicited immunity.

3D micro-environment regulates NF-κβ dependent adhesion to induce monocyte differentiation

This paper shows that 3D gel-like micro-environments induce monocyte differentiation through adhesion-MAPK-NF-κβ feedback, challenging the idea that adhesion is a result of differentiation.