Author

S. Chandrakumar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

I. Santiago Tierno· 3 shared K. Ghosh· 3 shared M. Agarwal· 3 shared N. Matisioudis· 2 shared T. S. Kern· 2 shared E. M. Lessieur· 1 shared J. Kiser· 1 shared J. Tang· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersPathology

I. Santiago Tierno

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3 papers

Recent·Most cited

Stiffness Measurement of Retinal Capillaries and Subendothelial Matrix using Atomic Force Microscopy

I. Santiago Tierno, M. Agarwal, N. Matisioudis, S. Chandrakumar, K. Ghosh

The paper provides a protocol for measuring retinal capillary and subendothelial matrix stiffness in mice using atomic force microscopy.

bioRxiv · Feb 28, 2024Pathology

Mechanical regulation of retinal vascular inflammation and degeneration in diabetic retinopathy

S. Chandrakumar, I. Santiago Tierno, M. Agarwal, E. M. Lessieur, Y. Du, J. Tang, J. Kiser, X. Yang, T. S. Kern, K. Ghosh

This study shows that retinal vascular stiffening, caused by LOX overexpression, mechanically regulates inflammation and degeneration in diabetic retinopathy, and that inhibiting LOX prevents these effects.

bioRxiv · Dec 18, 2022Pathology

Lysyl oxidase-dependent subendothelial matrix stiffening promotes RAGE-mediated retinal endothelial activation in diabetes

S. Chandrakumar, I. Santiago Tierno, M. Agarwal, N. Matisioudis, T. S. Kern, K. Ghosh

This study shows that LOX-dependent matrix stiffening, regulated by RAGE, promotes retinal endothelial activation in diabetes, suggesting new therapeutic targets for diabetic retinopathy.

bioRxiv · Aug 31, 2022Pathology