H3-K27M-Mutant Nucleosomes Interact with MLL1 to Shape the Glioma Epigenetic Landscape
N. Furth, D. Algranati, B. Dassa, O. Beresh, V. Fedyuk, N. Morris, L. Kasper, D. Jones, M. Monje, S. Baker, E. Shema
This study shows H3-K27M mutations alter chromatin marks by affecting PRC2 and MLL1 interactions, leading to bivalent chromatin and supporting glioma development.
bioRxiv · Aug 9, 2021Cancer Biology