A spindle and thread-mechanism unblocks translation of N-terminally disordered proteins
M. Kaldmae, T. Vosselman, X. Zhong, D. Lama, G. Chen, M. Saluri, N. Kronqvist, J. W. Siau, A. S. Ng, F. J. Ghadessy, P. Sabatier, B. Vojtesek, M. Sarr, C. Sahin, N. Osterlund, , M. Landreh
This study shows that fusing disordered proteins to an engineered spider silk domain improves their translation efficiency and activity in cells.
bioRxiv · Feb 22, 2021 · PreprintBiochemistry