A. Rising

Controlling Drug Partitioning in Individual Protein Condensates through Laser-Induced Microscale Phase Transitions.

This paper demonstrates laser-induced control of sol-gel transitions in protein condensates to enable drug loading.

Mass spectrometry of RNA-binding proteins during liquid-liquid phase separation reveals distinct assembly mechanisms and droplet architectures

The paper uses mass spectrometry and simulations to study phase separation of RNA-binding proteins, revealing distinct assembly mechanisms and droplet structures.

Molecular chaperone ability to inhibit amyloid-derived neurotoxicity, but not amorphous protein aggregation, depends on a conserved pH-sensitive Asp residue

The paper shows that a conserved Asp residue in BRICHOS domains is critical for inhibiting amyloid toxicity but not amorphous aggregation, with pH sensitivity and evolutionary conservation.

A spindle and thread-mechanism unblocks translation of N-terminally disordered proteins

This study shows that fusing disordered proteins to an engineered spider silk domain improves their translation efficiency and activity in cells.

Recombinant spider silk protein matrices facilitate multi-analysis of calcium-signaling in neural stem cell-derived AMPA-responsive neurons

This study shows that recombinant spider silk protein matrices support the differentiation of neural stem cells into functional AMPA-responsive neurons without animal or human-derived components.