BiochemistrybioRxivPreprint
Molecular chaperone ability to inhibit amyloid-derived neurotoxicity, but not amorphous protein aggregation, depends on a conserved pH-sensitive Asp residue
G. Chen, Y. Andrade-Talavera, X. Zhong…·J. Johansson
The paper shows that a conserved Asp residue in BRICHOS domains is critical for inhibiting amyloid toxicity but not amorphous aggregation, with pH sensitivity and evolutionary conservation.
DOI 10.1101/2021.12.01.470723