The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion
L. Onuchic, V. Padovano, G. Schena, V. Rajendran, K. Dong, N. P. Gresko, X. Shi, H. Shen, S. Somlo, M. J. Caplan
The study shows that a C-terminal fragment of PC1 suppresses cystic disease in a murine model by interacting with a mitochondrial enzyme, affecting metabolism and mitochondrial function.
bioRxiv · Dec 21, 2021 · PreprintPhysiology