The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model
J. Ruelas Castillo, P. Neupane, S. Karanika, S. Krug, D. Quijada, A. Garcia, S. Ayeh, A. Yilma, D. L. Costa, A. Sher, N. Fotouhi, N. Serbina, P. C. Karakousis
This paper evaluates the adjunctive effect of the HO-1 inhibitor stannsoporfin in combination with a novel MDR-TB regimen in a murine model, showing reduced lung bacillary burden but no effect on microbiological relapse.
bioRxiv · Aug 9, 2023Microbiology