P. C. Karakousis

This paper evaluates the adjunctive effect of the HO-1 inhibitor stannsoporfin in combination with a novel MDR-TB regimen in a murine model, showing reduced lung bacillary burden but no effect on microbiological relapse.

This study identifies Mtb genes involved in antibiotic tolerance under nutrient-starved conditions through a functional genome screen, revealing potential therapeutic targets.

This study identifies transcriptomic changes and virulence factors in Mycobacterium tuberculosis during bone tuberculosis, revealing metabolic shifts and cell wall remodeling strategies for survival in the host.

This study shows that male golden Syrian hamsters experience more severe lung disease and lower antiviral antibody responses compared to females after SARS-CoV-2 infection.

This study identifies antibiotic tolerance genes in Mycobacterium avium through a genome-wide transposon screen, revealing potential targets for improving treatment of MAC infections.

This study identifies essential genes in Mycobacterium avium subsp. hominissuis using Tn-Seq and a rank-based filter, finding 270 essential features overlapping with those in Mycobacterium tuberculosis.

This study shows that antibiotic treatment alters antigen presentation during TB, and therapeutic vaccination targeting RelMtb enhances isoniazid efficacy against Mtb persisters.