MicrobiologybioRxiv
The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model
J. Ruelas Castillo, P. Neupane, S. Karanika…·P. C. Karakousis
This paper evaluates the adjunctive effect of the HO-1 inhibitor stannsoporfin in combination with a novel MDR-TB regimen in a murine model, showing reduced lung bacillary burden but no effect on microbiological relapse.
DOI 10.1128/aac.01043-23