Author

N. Sipari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Evolutionary Biology· 1 Pathology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. Purhonen· 2 shared L. Paulin· 2 shared P. Auvinen· 2 shared R. Banerjee· 2 shared V. Fellman· 2 shared A. J. Fleming· 1 shared A. Jaiswal· 1 shared A. K. Pandey· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

J. Purhonen

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Author profile →

5 papers

Recent·Most cited

Enzymatic assay for UDP-GlcNAc and its application in the parallel assessment of substrate availability and protein O-GlcNAcylation

M. Sunden, D. Upadhyay, R. Banerjee, N. Sipari, V. Fellman, J. Kallijärvi, J. Purhonen

This paper introduces an enzymatic assay to measure UDP-GlcNAc and applies it to assess substrate availability and O-GlcNAcylation in mouse tissues and cells.

bioRxiv · Mar 18, 2023Biochemistry

Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria

J. Purhonen, R. Banerjee, V. Wanne, N. Sipari, M. Morgelin, V. Fellman, J. Kallijarvi

This study shows that mitochondrial complex III deficiency causes c-MYC overexpression, leading to senescence and progeria-like symptoms in mice.

bioRxiv · Jan 10, 2023Pathology

Convergent evolution of mevalonate pathway in Inonotus obliquus and Betula pendula.

O. Safronov, G. Lutfullahoglubal, N. Sipari, M. Wilkens, P. Safdari, O.-P. Smolander, J. Lihavainen, N. Silvan, S. Rajaraman, P. K. Laine, L. Paulin, P. Auvinen, T. Sarjala, K. Overmyer, J. Kangasjarvi, , J. Salojarvi

The paper sequenced the Chaga mushroom genome and found lineage-specific whole genome duplication and Cytochrome P450 expansion, leading to complex terpene biosynthesis.

bioRxiv · Nov 28, 2021 · PreprintEvolutionary Biology

Genetic screen to saturate guard cell signaling network reveals a role of GDP-L-fucose metabolism in stomatal closure

C. Waszczak, T. Vahisalu, D. Yarmolinsky, M. Sierla, O. Zamora, M. Leal Gavarron, J. Palorinne, R. Carter, A. K. Pandey, M. Nuhkat, M. Carmody, T. Puukko, N. Sipari, A. Lamminmäki, J. Durner, , J. Kangasjärvi

The paper identifies a novel role for GDP-L-fucose metabolism in stomatal closure through a genetic screen, revealing defects in fucose-related processes affect guard cell function.

bioRxiv · Jun 4, 2020Plant Biology

Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor

A. Jaiswal, P. Gautam, E. A. Pietila, S. Timonen, N. Nordstrom, Z. Tanoli, N. Sipari, K. Lehti, K. Wennerberg, T. Aittokallio

The paper integrates multi-modal omics data from cancer cell lines to identify ECHDC1 as a novel breast tumor suppressor and discover synthetic lethal interactions.

bioRxiv · Jan 31, 2020Cancer Biology