PathologybioRxiv
Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria
J. Purhonen, R. Banerjee, V. Wanne…·J. Kallijarvi
This study shows that mitochondrial complex III deficiency causes c-MYC overexpression, leading to senescence and progeria-like symptoms in mice.
DOI 10.1038/s41467-023-38027-1