Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage Reprogramming
N. Thielman, V. Funes, S. Davuluri, H. lbanez, W.-C. Sun, J. Fu, K. Li, S. Muth, X. Pan, K. Fujiwara, D. Thomas, M. Henderson, S. S. Teh, Q. Zhu, E. Thompson, , L. Zheng
This study identifies SEMA3D as a dual driver of pancreatic ductal adenocarcinoma progression and metastasis through tumor- and nerve-derived mechanisms involving macrophage reprogramming.
bioRxiv · Oct 24, 2023 · PreprintCancer Biology