F. Meng

Optimizing genomic prediction for complex traits via investigating multiple factors in switchgrass

This study evaluates factors affecting genomic prediction accuracy in switchgrass, finding that exome capture and multi-allelic variants improve predictions for complex traits.

Bola-amphiphilic dendrimer empowers imatinib to target metastatic ovarian cancer stem cells via beta-catenin-HRP2 signaling axis

This study develops a nanoformulation Bola/IM to target metastatic ovarian cancer stem cells via the beta-catenin-HRP2 signaling axis, showing improved efficacy and synergy with cisplatin.

Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions

This study shows that PV antibodies cause tension loss at desmosomes and cell-cell adhesions by inhibiting RhoA, which can be partially reversed by altering actomyosin contractility.

NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model

This study shows NPRL2 gene therapy reduces lung metastases in KRAS/STK11 mutant NSCLC in humanized mice by enhancing immune cell infiltration and reducing T cell inhibitory signals.

Mitochondrial fission surveillance is coupled to Caenorhabditis elegans DNA and chromosome segregation integrity

The paper identifies genes regulating mitochondrial fission in C. elegans and shows that chromosome missegregation leads to mitochondrial fission dysregulation, independent of Drp-1.

Biosynthesis of the proteins containing neurotoxin β-N-methylamino-L-alanine in marine diatoms

This study investigates how iron limitation increases BMAA-containing protein production in marine diatoms and identifies cysK as a key enzyme in BMAA biosynthesis.

SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling

This study identifies SARS-CoV-2 NSP13 as a suppressor of Hippo-YAP signaling by interacting with TEAD and remodeling chromatin to inhibit YAP transcriptional activity.

Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage Reprogramming

This study identifies SEMA3D as a dual driver of pancreatic ductal adenocarcinoma progression and metastasis through tumor- and nerve-derived mechanisms involving macrophage reprogramming.

Base Excision Repair Pathway Regulates Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma

This study identifies the base excision repair pathway as a regulator of transcription-replication conflicts in pancreatic ductal adenocarcinoma, showing that its inhibition enhances DNA damage and reduces cell proliferation.

Inflammation plays a critical role in damage to the bronchiolar epithelium induced by Trueperella pyogenes in vitro and in vivo

This study investigates T. pyogenes-induced damage to bronchiolar epithelium in vitro and in vivo, identifying inflammatory pathways and potential therapeutic targets.

Assembly of sequences of Northern China alligatorweed identifies processes and gene ontologies associated with invasiveness and provides genomic resources for population and gene regulation studies

The paper assembles transcriptomes and genomes of alligatorweed to identify gene ontologies linked to invasiveness and provides genomic resources for further studies.

Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming

This study shows histone lactylation counteracts senescence and skeletal muscle aging by reprogramming gene expression, with exercise enhancing lactylation and improving muscle function.

Cryo-EM complex structure of active GPR75 with a nanobody

The paper reports the Cryo-EM structure of active GPR75 with a nanobody, revealing its activation mechanism and providing a structural basis for anti-obesity drug discovery.

Brassinosteroids signaling component SlBZR1 promotes fruit ripening in tomato

This study shows that brassinosteroids promote tomato fruit ripening by enhancing ethylene production and carotenoid accumulation through the SlBZR1 transcription factor.

AHR agonist ITE boosted PD1 antibodys effects by inhibiting myeloid-derived cells suppressive cells in an orthotopic mouse glioma model

The paper shows that ITE, an AHR agonist, enhances PD1 antibody efficacy in a glioma model by reducing MDSCs and increasing CD8+ T cell infiltration.

3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib

This study identifies PDK1 as a driver of osimertinib resistance in NSCLC, showing its inhibition sensitizes resistant cells and correlates with disease progression.

Remarkable Adsorption Performance of Rutile TiO2 (110) Nanosheet for DNA Nucleobases: A First-Principles Study

This study uses first-principles calculations to show rutile TiO2 (110) nanosheets have strong adsorption for DNA nucleobases, exceeding graphene by over 20 times, with implications for DNA sensors and sequencers.

ERα-LBD, a novel isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance

The paper identifies ER-LBD, a novel estrogen receptor alpha isoform, which promotes breast cancer growth and resistance to endocrine therapy.

Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants

This study examines the correlation between vaccine-induced IgG levels and neutralizing titers against SARS-CoV-2 and its variants, finding a significant positive correlation and reduced neutralization against variants.

Phage Display Broadly Identifies Inhibitor-reactive Regions in von Willebrand Factor

This study uses phage display and NGS to identify inhibitor-reactive regions in von Willebrand factor, revealing distinct patterns among patients and overlap with a commercial antibody.

Brassinosteroid signaling component SlBES1 promotes tomato fruit softening through transcriptional repression of PMEU1

This study identifies SlBES1 as a regulator of tomato fruit softening by repressing PMEU1, leading to firmer fruits with extended shelf life without affecting visual or nutritional quality.

Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

A First-in-class, Highly Selective and Cell-active AllostericInhibitor of Protein Arginine Methyltransferase 6 (PRMT6)

This paper reports the discovery of a first-in-class, highly selective allosteric inhibitor of PRMT6, SGC6870, with potent activity and selectivity in vitro and in cells.

Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation

The paper identifies molecular mechanisms of neuroendocrine transformation in lung cancer using multi-omic analysis of tumors and clinical samples.

Bioassemblying Macro-Scale, Lumnized Airway Tubes of Defined Shape via Multi-Organoid Patterning and Fusion

This paper introduces MOrPF, a method to assemble airway organoids into scaffold-free, shape-defined tubes, demonstrating shape stability and epithelial characteristics.

Heterogeneous aggregation of amyloid-β 42 from single-molecule spectroscopy

This study uses single-molecule spectroscopy and deep learning to analyze the heterogeneous aggregation of Aβ42, revealing low oligomer concentrations and diverse conformations, and proposes a new aggregation model.

Genome-wide predictions of genetic redundancy in Arabidopsis thaliana

This study develops a machine learning model to predict genetic redundancy in Arabidopsis thaliana using diverse features, identifying key predictors like recent duplication and stress-related expression.

Glycopeptidomics Analysis of a Cell Line Model Revealing Pathogenesis and Potential Marker Molecules for the Early Diagnosis of Gastric MALT Lymphoma

The paper uses glycopeptidomics to analyze host cell lines and identify specific glycopeptides associated with gastric MALT lymphoma, offering potential markers for early diagnosis.

Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiate the DNA damage response and repair

This study shows that SIRT1 and SIRT6 work together to recognize DNA breaks and enhance the DNA damage response and repair.

Correlation between Serum Kisspeptin and Spermatogenic Function in Men

This study examines the relationship between serum kisspeptin levels and male fertility, finding a strong correlation with sperm concentration and a potential threshold to distinguish obstructive from non-obstructive azoospermia.