Two-stage electro-mechanical coupling of a Kv channel in voltage-dependent activation
P. Hou, P. W. Kang, A. Deyawe Kongmeneck, N.-D. Yang, Y. Liu, J. Shi, X. Xu, K. M. White, M. A. Zaydman, M. A. Kasimova, G. Seebohm, L. Zhong, X. Zou, M. Tarek, J. Cui
The paper identifies a two-stage electro-mechanical coupling mechanism in KV7.1 channels, where VSD transitions through intermediate and activated states to trigger pore opening.
bioRxiv · Oct 9, 2019Biophysics