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11 papers
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P. HOU, L. ZHAO, L. ZHONG, J. Shi, H. WANG, J. GAO, H. LIU, J. Zuckerman, I. S. COHEN, J. Cui
This paper identifies the fully activated open state of KCNQ1 as critical for β-adrenergic stimulation of IKs channels, showing that modulators enhancing this state can restore function in LQT1 mutants.
bioRxiv · Jul 2, 2024Biophysics
L. Yi, L. p. fei, Y. Zhang, H. Lang, P. Hou, Y. Yao, R. Zhang, X. Wang, Q. Zhang, M. Mi
This study shows that dihydromyricetin improves insulin resistance by enhancing GLP-1 secretion through the gut microbiota-CDCA pathway in HFD-induced mice.
bioRxiv · May 28, 2024 · PreprintPharmacology & Toxicology
V. V. Nowak, P. Hou, J. G. Owen
The paper develops a pipeline to analyze microbial communities in marine sponges and identifies biosynthetic novelty in their associated microbes.
bioRxiv · Jan 9, 2024 · PreprintMicrobiology
A. K. Dou, P. W. Kang, P. Hou, M. A. Zaydman, J. Zheng, T. Jegla, J. Cui
The paper uses statistical coupling analysis to study sensor-effector organization in TRP and Kv ion channels, identifying conserved core sectors and family-specific accessory sectors with three localization principles.
bioRxiv · Aug 3, 2021 · PreprintBiophysics
Y. Lin, S. Z. Grinter, Z. Lu, X. Xu, H. Z. Wang, H. Liang, P. Hou, J. Gao, C. Clausen, J. Shi, W. Zhao, Z. Ma, Y. Liu, K. M. White, L. Zhao, , J. Cui
This study identifies C28 as a compound that modulates IKs channel voltage sensor activation, reversing drug-induced APD prolongation without affecting normal APD.
bioRxiv · Feb 25, 2021Biophysics
M. Zhu, R. Peng, X. Liang, Z. Lan, M. Tang, P. Hou, J. H. Song, C. S. L. Mak, J. Park, S.-e. Zheng, A. Huang, X. Ma, R. Chen, Q. Chang, C. J. Logothetis, , G. Wang
This study identifies P4HA2-dependent prolyl hydroxylation of YAP1 as a suppressor of prostate cancer cell migration, invasion, and metastasis.
bioRxiv · Jan 24, 2021Cancer Biology
B. Qin, G. B. Craven, P. Hou, X. Lu, E. S. Child, R. M. L. Morgan, A. Armstrong, D. J. Mann, S. Cui
The paper identifies acrylamide fragments that covalently inhibit EV71 3Cpro and SARS-CoV-2 Mpro by targeting their active site cysteine, inducing conformational changes and allosteric effects.
bioRxiv · Nov 6, 2020Biochemistry
X. Hu, W. Hao, B. Qin, Z. Tian, Z. Li, P. Hou, R. Zhao, S. Cui, J. Diao
This paper investigates the unwinding mechanism of coronavirus nsp13 helicases using single-molecule FRET, revealing distinct step sizes and NTP hydrolysis patterns between MERS-CoV and SARS-CoV-2 nsp13.
bioRxiv · Aug 2, 2020 · PreprintBiophysics
P. Hou, P. W. Kang, A. Deyawe Kongmeneck, N.-D. Yang, Y. Liu, J. Shi, X. Xu, K. M. White, M. A. Zaydman, M. A. Kasimova, G. Seebohm, L. Zhong, X. Zou, M. Tarek, J. Cui
The paper identifies a two-stage electro-mechanical coupling mechanism in KV7.1 channels, where VSD transitions through intermediate and activated states to trigger pore opening.
bioRxiv · Oct 9, 2019Biophysics
N. Gao, P. Hou, Q. Zhang, W. Mu, J. Wang, D. Wang, A. Li
The paper investigates the inverse relationship between fibronectin and neuroligins in the embryonic rat colon, showing direct regulation and negative correlation.
bioRxiv · Sep 5, 2019 · PreprintCell Biology
P. Hou, J. Shi, K. M. White, Y. Gao, J. Cui
This study shows ML277 enhances the AO state of KCNQ1 channels by improving VSD-pore coupling, offering a potential therapy for long QT syndrome.
bioRxiv · May 2, 2019 · PreprintBiophysics